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The role of radiologist assistant in radioiodine diagnostics and treatment of thyroid cancer
Hrbek, Jaroslav ; Táborská, Kateřina (referee) ; Vlček, Petr (advisor)
The bachelors thesis on the task of a radiological assistant during radioiodine diagnostics and treatment of thyroid gland carcinomas deals with the issue of thyroid gland carcinomas in the Czech Republic. It contains a brief overview of the types of carcinomas that affect the thyroid gland, their classification, diagnostics and therapy, concentrating on utilisation of modern examination methods and therapeutic practices, including among others application of radioiodine. The thesis also contains cases of four patients with similar diagnoses, the comparison of the development of whose respective illnesses I found interesting. Last but not least, the thesis includes a number of annexes comprising among others tables with important instructions for patients before and after application of radioiodine, and photographs from the site where the radioiodine application takes place Powered by TCPDF (www.tcpdf.org)
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Laboratory diagnosis of thyroid hormones in clinical medicine
KAVICKÁ, Andrea
Diseases of thyroid gland are the most common endocrine disorders after diabetes mellitus. Laboratory diagnostics has irreplaceable role in the diagnostics of thyroid gland disorders. The first part describes the various thyroid diseases, their causes, symptoms, treatment and diagnostics. The second part this work includes meaning and the principle of individual parameters examinated for monitoring of thyroid gland disorders. Examination of the parameters of the thyroid gland is a very busy immunoassay methods. Methods of the thyroid gland used for determining the functional status of the thyroid gland. Inform us about the etiology, monitoring therapy and based on that choose treatment procedure. Thyreotropin is a very sensitive and specific marker for evaluating the function of thyroid gland and simultaneously appropriate for early detection or exclusion of thyroid disorders. In the case of TSH out of reference limit we set further examination fT4, rarely fT3. TSH and free fraction´s of thyroxine and trijodthyronine performed on the analyzer Roche Modular E, which uses methods ECLIA. Detection of antibodies were determined by using analyzer from Siemens company Immulite XPi, which is based on chemiluminescent immunometric analysis. Examination of anti-Tg and anti-TPO tell us a lot about the etiology of testing in the case of autoimmune disease. I investigated 830 patients, 299 men and 531 women, where on the based TSH out of reference limit diagnostic hypothyroidism and hyperthyroidism. My research, I am allowed to supplement the expertise of the doctors who requested the examination of thyroid hormones In the end this work is graphically represented frequency determination of hormones and thyroid autoantibodies for the year 2013 in our laboratory.
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The effect of iodine on functional parameters of ewes.
DUŠOVÁ, Hana
The aim of this work was to assess the long-term effect of excessive iodine intake on thyroid activity and selected immunological, haematological and biochemical parameters in blood of ewes and their lambs. The experiment was conducted from August 2009 to February 2010 in an experimental barn of Faculty of Agriculture, University of South Bohemia in České Budějovice. Into the experiment were used Šumava sheep breed ewes and their born lambs. Group A (control) consisted of 6 ewes after lambing was extended to 7 born lambs, group B (experimental) 6 of 6 ewes and lambs. Lambs were put into the experiment from the 1st to the 60th day after birth and received iodine in the milk of their mothers. Iodine supplementation to the diet of ewes was launched during the first to second months of pregnancy and finished 60 days after birth. During the experiment, a group of ewes A received 3,1 and group B 5,1 mg iodine per kg of dietary dry matter in the form of calcium iodate. During the experiment was regularly collected blood of ewes (before lambing and 1st, 10th, 30th and 60th day after birth) and lambs (1st, 3rd, 10th, 30th and 60th day after birth) to determine the concentration of thyroid stimulating hormone and immunoglobulin G (ELISA) in blood serum, thyroid hormones (RIA), total protein, urea and alkaline phosphatase activity in the blood plasma (biochemical analyser), the content of haemoglobin, white blood cell´s and red blood cell´s counts and haematocrit values in blood (haematological analyser), percentage of albumin, -1-globulins, -2-globulins, -globulins, and -globulins in blood serum (electrophoresis) and the content of iodine in the blood plasma, urine and milk of ewes (colorimetric method Sandell-Kolthoff). During the experiment were not observed in ewes and lambs clinical symptoms associated with an excessive intake of iodine. In experimental group of ewes with iodine intake 5,1 mg/kg of dietary dry matter were found higher values of thyroid stimulating hormone, lower values of free triiodothyronine, free thyroxine, IgG, white blood cells, -1-globulins, -2-globulin and -globulin, significantly lower values of -globulins after parturition, significantly higher values of urea and alkaline phosphatase activity. The iodine content in blood plasma, milk and urine of ewes is increased in direct proportion to its concentration in diet. Lambs of mothers with iodine intake of 5,1 mg/kg of dietary dry matter were significantly higher values of thyroid stimulating hormone from the 10th day after birth, significantly lower values of free triiodothyronine and free thyroxine first day after birth, immunoglobulin G and -globulins in 30th day after birth, lower (statistically significant in middle samples) values of total protein and white blood cells, higher values of urea and alkaline phosphatase activity. The weight gains of lambs were not significantly affected by iodine supplementation. These results in ewes with iodine intake of 5,1 mg/kg dietary dry matter and especially their lambs drawn to risk of reduce the activity of the thyroid gland and the negative impact of parameters of humoral immunity, mainly IgG and -globulins.
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